The Old City Hospital in St. Louis operated from 1845 to 1985. The present-day structure dates to 1896. Initially founded to deal with a severe cholera outbreak, the City of St. Louis owned and operated the hospital for nearly a century and a half.
Old City Hospital in St. Louis occupied five city blocks at the intersection of 14th and Lafayette Avenue. A public hospital serving the poor and uninsured, it had a capacity of approximately 1,100 beds.